PNC-27 10mg research peptide vial by FYH Peptides
COA Verified
Immunology Research Cat№ FYH-021

PNC-27

10mg • Lyophilized
$132.74 USD / vial

32-amino-acid synthetic peptide containing a p53/HDM-2 binding-domain fragment fused to a membrane-residency sequence. Research-grade compound for in vitro tumor-cell line study.

Technical Data

Catalog №
FYH-021
CAS №
Research compound (no public CAS)
Purity (HPLC)
98.50%
Mol. Weight
≈ 3300 g/mol
Mass / Vial
10mg
Form
Lyophilized
Storage
−20 °C, lyophilized
Origin
Switzerland, GMP-grade synthesis
Sequence / Structure
p53/HDM-2 binding domain fragment + membrane-residency sequence

Certificate of Analysis

COA available on request — contact us for the latest batch report.

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Published Research

Peer-reviewed literature indexed on NCBI PubMed referencing PNC-27. Listed for laboratory reference only — FYH Peptides makes no claim regarding the conclusions of any cited author. Click PubMed or DOI to read the original publication. Updated 2026-05-20.

  1. 1.
    PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
    Sarafraz-Yazdi E, Mumin S, Cheung D, et al.
    Biomedicines · 2022
    PubMed DOI 10.3390/biomedicines10050945 PMID: 35625682
  2. 2.
    The role of ETFS amino acids on the stability and inhibition of p53-MDM2 complex of anticancer p53-derivatives peptides: Density functional theory and molecular docking studies.
    Soriano-Correa C, Vichi-Ramírez MM, Herrera-Valencia EE, et al.
    Journal of molecular graphics & modelling · 2023
    PubMed DOI 10.1016/j.jmgm.2023.108472 PMID: 37086514
  3. 3.
    Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption.
    Krzesaj P, Adler V, Feinman RD, et al.
    Annals of clinical and laboratory science · 2024
    PubMed PMID: 38802154
  4. 4.
    HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical Cells.
    Krzesaj PK, Seydafkan S, Miller AI, et al.
    Annals of clinical and laboratory science · 2025
    PubMed PMID: 40750238
  5. 5.
    Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells.
    Thadi A, Lewis L, Goldstein E, et al.
    Anticancer research · 2020
    PubMed DOI 10.21873/anticanres.14488 PMID: 32878773
  6. 6.
    Conjugated PNC-27 peptide/PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for early cancer diagnosis: In vitro study.
    Rahmani R, Darroudi M, Gharanfoli M, et al.
    Iranian journal of basic medical sciences · 2022
    PubMed DOI 10.22038/IJBMS.2022.65590.14430 PMID: 36311203
  7. 7.
    The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.
    Sookraj KA, Bowne WB, Adler V, et al.
    Cancer chemotherapy and pharmacology · 2010
    PubMed DOI 10.1007/s00280-009-1166-7 PMID: 20182728
  8. 8.
    The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
    Davitt K, Babcock BD, Fenelus M, et al.
    Annals of clinical and laboratory science · 2014
    PubMed PMID: 25117093
⚠️ For Research Use Only. This product is sold exclusively for in vitro laboratory research use by qualified researchers and laboratories. It is NOT intended for human consumption, medical use, or as a dietary supplement. The FDA has not evaluated this product for safety or efficacy.

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